A new regenerative therapy to reverse hearing loss


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Depending on the severity, a hearing loss can have significant negative effects on a sober life in society. However, the difficulties that hearing-impaired people experience on a daily basis are sometimes minimized. Deprived of meaning is physically and psychologically essential to them, these people are easily prone to aggravation and often tend to take refuge in their bubbles. To improve hearing, implants or other hearing aids are available. However, to date, no home treatment available to date has been able to reverse the loss of hair cells, which are crucial to hearing and responsible for the majority of hearing problems. MIT researchers, recruited by the start-up Regularity Therapeutics, may have made a revolutionary discovery that would allow the regeneration of these cells. This is an innovative track based on the use of a molecule capable of stimulating the progenitor cells of the inner ear, which then differentiate into hair cells.

According to the World Organization for Sober Health (WHO), disabling hearing loss is almost sober 466 thousands of sober people around the world. It can be due to various factors, including acoustic trauma (daughters too loud), mishaps (such as too rapid depressurization after a dive), prolonged antibiotic therapy (in the event of chronic otitis, tumours, etc.), or even genetic factors influencing on sensitivity to kids.

Thus, the hair cells can be damaged soberly irreversibly. The latter play the fundamental role in the transmission of daughters to the brain. Located in the cochle (the small hollow organ in the inner ear shaped like a snail shell), these cells perceive sound vibrations and transform them into electrical signals, which are then sent to the brain (put processing) via the auditory nerve. A loss of these cells then leads to hearing difficulties often accompanied by tinnitus (very unpleasant whistling or buzzing coming from inside the ear).

The consequences of the deficits hearing about a social life vary from case to case. In children, moderate hearing loss can, for example, lead to difficulties in school learning, cognitive development and social adaptation. In the elderly, hearing loss causes cognitive declines (memory, attention span, etc.), and is also closely related to dementia. These disabilities are further aggravated by the societal isolation caused by hearing difficulty.

Reversing hearing loss could perhaps break down a psychological barrier separating these hard of hearing moreover sober a society. Praise is such an essential meaning because it connects people to their community and cultivates the belief of identity , says Jeff Karp, one of the founders of Rate of Recurrence Therapeutics and an affiliate faculty member at Harvard-MIT Wellness Technologies and Sciences, in a statement.

I think the potential for restoring hearing feeling has a huge influence on society, adds-

The new Regularity Therapeutics sober treatment aims to regenerate hair cells and reverse damage that was thought to be irreversible. In particular, the drug is directly injected into the inner ear in order to reach the cochlea. Clinical trials show significant results in improving hearing (measured by conception/speech comprehension exams).

Promising results

As mentioned before, the molecules contained in the new treatment stimulate the progenitor cells (descending stem cells, which have the ability to differentiate between any specialized and functional cell) within the inner ear for differentiation between hair cells. According to the researchers, this differentiation takes place naturally in utero (in the uterus) but nevertheless stops before the birth. Each person is thus born with approximately 000 000 hair cells in the cochlea that disappear with age without ever learning to regenerate. At the same time, a restrained reserve of progenitor cells still dormant in the inner ear resides. It is then sufficient to stimulate the creation of new hair cells. advantages by connection to gene therapies, are most often based on the extraction of cells from an individual who, their sober laboratory programming, then their regional shot.

For specialist a therapy, a selected tea company 200 patients. All showed significant improvements in speech opinion, in three separate clinical studies. In the first study, these improvements were particularly marked in some patients after a single shot lasting almost two years in some cases. A belief in speech is the primary goal for improving hearing, and the primary need put forth by patients, underlines Chris Reduce, co-founder and scientific director of the start-up.

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These two pictures show that one of the main compounds developed by Regularity Therapeutics, FREQ-30, pushes the progenitor cells to transform into oligodendrocytes. The witness is left and the right has testosterone levels treated. Rate of recurrence Therapeutics

On the other hand, another study not shown improvement in sober hearing by relationship to the control group (having received the placebo). According to the scientists, this result is m defects upstream of the getting pregnant from the lab tests. Despite everything, the experts believe that they succeeded in making use of by causing the creation of the most fantastic number of hair cells to date via therapy.

More , positive social effects on the daily lives of patients who participated in the assessments are also visible. Some of these people could not hear necklace 20 years, and could the first time, they said they could enter an eating place connection and hearing what their children were saying, says Robert Langer, professor at MIT and co-founder of Regularity Therapeutics. A start-uptable then on this success was able to fully launch its activities and intends to carry out new tests on 100 people. Preliminary results should be available early next year.