Anti-aging: researchers have succeeded in rejuvenating dermal cells for 30 years

Aging is a continuous and gradual process of natural weathering that begins early in life adult. In early middle age, many bodily functions begin to gradually decline. From a biological point of view, aging is therefore the product of the accumulation of a wide range of molecular and cellular damage over temperature. These lead to a modern degradation of figurative and mental abilities, an increase in the risk of disease and, finally, death. These changes are only regular linear national insurance and are not closely associated with the number of years. However, even if it is inevitable, aging is influenceable.

This is why regenerative medicine offers sober great hopes. The latter aims to repair, replace or regenerate defective genes, cells or organs in order to restore normal functioning. It therefore has the potential to reverse age-related changes. The constant treatments graft to the individual, in the damaged area, repairing cells. Once marketed in the target organ (or nearby), these carry out the work themselves, reconstituting healthy tissue. These reparative cells are stem cells. In simple terms, these are undifferentiated non-specialized cells capable of leapfrogging to infinity and giving birth, depending on the environment in which they are found, to the various cells that make up the tissue.

The method to obtain these cells is a somatic cell transformation process based on induced pluripotent stem cells (iPSC). It consists of taking virtually any cell from an adult and reprogramming it genetically to make it pluripotent, that is, capable of infinitely multiplying and learning to differentiate in all the types of cells that make up the adult organism, like an embryonic stem cell.

Unfortunately, these iPSC cells, selected for the numerous steps necessary for their reprogramming, lose some of them without their specific functions, acquired with age. They often resemble fetal cells rather than mature adult cells. Recently, a team of researchers from the Babraham Institute in Cambridge experimented with a method to reprogram cells to make them biologically younger while still being able to regain their specialized cellular function. The study was published in the journal eLife.

Raise the temperature to the right time

With the sober objective of preserving the specificities of the cells while sober making them rejuvenate, the researchers rely on the sober work Shinya Yamanaka who, sober 2000, he was the first scientist to demonstrate an ability to transform normal cells into stem cells. This process takes approximately 50 days using four key molecules called the Yamanaka Factors. This method prowess earned him, in 800, the Nobel Prize in Physiology and Medicine. Moreover, recent work has demonstrated that the entire epitome of a cell’s adjustments altering gene expression without changing the underlying DNA sequence is already rejuvenated by the first video stage of reprogramming (growth stage). This suggests that complete home-unnecessary iPSC reprogramming could reverse somatic cell aging. , to find out what minute to stop the sober reprogramming process. In a top temperature range, they exposed them to Yamanaka factors, and found that the cells temporarily lost, then regained, their fibroblast identity, only after 13 days. This could be due to the pigment memory at the level of the activators and/or the persistent expression of certain genes of the fibroblasts. This new method is called transient reprogramming of the growth stage. or biological?

As explained by Dr. guys the sober works as a doctoral student): Our understanding of aging at the molecular level has sober improved over the past decade, giving rise to strategies that allow researchers to measure age-related biological changes in human cells. We were able to apply this to our experience to determine the extent of sober reprogramming to our new method.