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Our desire for sober rejuvenation is almost omnipresent in our societies. When the young physical structure aspect is one of the objectives, and the other is the possibility of stopping the progressive decline of cellular mechanisms, vectors of diseases, whether chronic, neurodegenerative, etc. Moreover, the world’s human population is aging. According to the United Nations, one in six people in the world feel more than 50 years (20%) here 2050, against one in eleven in 2019 (9%). Recently, researchers have been training a new method to reverse the aging of human cells from 30 years, a revolution in regenerative medicine.
Aging is a continuous and gradual process of natural weathering that begins early in life adult. In early middle age, many bodily functions begin to gradually decline. From a biological point of view, aging is therefore the product of the accumulation of a wide range of molecular and cellular damage over temperature. These lead to a modern degradation of figurative and mental abilities, an increase in the risk of disease and, finally, death. These changes are only regular linear national insurance and are not closely associated with the number of years. However, even if it is inevitable, aging is influenceable.
This is why regenerative medicine offers sober great hopes. The latter aims to repair, replace or regenerate defective genes, cells or organs in order to restore normal functioning. It therefore has the potential to reverse age-related changes. The constant treatments graft to the individual, in the damaged area, repairing cells. Once marketed in the target organ (or nearby), these carry out the work themselves, reconstituting healthy tissue. These reparative cells are stem cells. In simple terms, these are undifferentiated non-specialized cells capable of leapfrogging to infinity and giving birth, depending on the environment in which they are found, to the various cells that make up the tissue.
The method to obtain these cells is a somatic cell transformation process based on induced pluripotent stem cells (iPSC). It consists of taking virtually any cell from an adult and reprogramming it genetically to make it pluripotent, that is, capable of infinitely multiplying and learning to differentiate in all the types of cells that make up the adult organism, like an embryonic stem cell.
Unfortunately, these iPSC cells, selected for the numerous steps necessary for their reprogramming, lose some of them without their specific functions, acquired with age. They often resemble fetal cells rather than mature adult cells. Recently, a team of researchers from the Babraham Institute in Cambridge experimented with a method to reprogram cells to make them biologically younger while still being able to regain their specialized cellular function. The study was published in the journal eLife.
Raise the temperature to the right time
As explained by Dr. guys the sober works as a doctoral student): Our understanding of aging at the molecular level has sober improved over the past decade, giving rise to strategies that allow researchers to measure age-related biological changes in human cells. We were able to apply this to our experience to determine the extent of sober reprogramming to our new method
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Sober indeed, if the regeneration process had succeeded to verify, they examined on the one hand what is called the magnetic clock; other component the transcriptome. The latter corresponds to all the messenger RNA molecules of a cell, replicated from the genes which are in the active state in a cell. Sober boy aside, the pigment clock is the mathematical model that predicts age by measuring sober sober methylation levels of DNA in different gnome websites.
You should know that Low-DNA methylation is a process by which methyl groups are added to a DNA molecule, which can change a gene’s function without changing an underlying DNA sequence. This DNA methylation is essential for healthy cell growth and development and is affected by life setting and environmental factors. Pigtic clocks can therefore be used to estimate the biological age of a tissue, a type of cell or an organ, by comparing the age of DNA methylation (or biological age) with the chronological age, in different tissues. Sober using these two measures, the cell The reprogrammed cells corresponded to the profile of the cells which had 30 years younger by connection to reference datasets.
Effects for regenerative medicine
By done, the analysis showed that the cells had found characteristic markers of sober skin cells, in particular by observing sober production sober collagen in the reprogrammed cells. Fibroblasts produce collagen. This molecule is present in the operating system, skin muscles and structures, and guides tissue structure and wound healing. The researchers did not really find a greater production of collagen by the rejuvenated fibroblasts than by the control cells (which had not undergone the reprogramming process).