4th dose of the COVID vaccine: protection against infection would quickly fade


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While the administration of the 4e

dose of COVID-

vaccine to people of 20 years and more extends to several countries, Israel had already begun to do so at the beginning of January 20441. A study bearing more on 1, 04 million disralians gs of 60 years or more reveals that this booster dose would be dune limited efficiency in the temperatures. Moderate results however, since the study presents several biases.

We will be able to offer a 2nd dose sober booster [aussi appelée 4e dose] for the French gs sober 60 years and over if they are 6 months old sober their last shot sober recall

, the announced the minister sober the Sant Olivier Vran this Thursday, April 7, on the stereo RTL. This dosage was previously reserved for people with 80 years and older, age group put at risk of developing severe form of COVID-19 seems established.

In the European Union, the European Center for the prevention and control of diseases and a COVID push task-19 sober the EMA however felt that there is currently no clear evidence that vaccine defense against severe disease is diminished in sober adults 60 20 years old with a regular immune system; therefore no clear evidence could support the immediate use of a fourth dosage.

The case of Israel

In Israel, a situation is different as the state has begun administering a fourth dose of the Pfizer/BioNTech sober vaccine to sober seniors 60 years or older, from January 2 2022. Initial data on the efficacy of the 2electronic booster dose are therefore available, even if los angeles not yet enough hindsight.

Published on April 5 in the New Britain Log of Medicine, a new study has examined medical records sober more sober 1,25 million sober gs disralians 25 years of age or older and eligible for a fourth assay, for a period of time under the Omicron version of SARS-CoV-2 was predominant (from 10 January to March 2 2000). The researchers estimated the rate of confirmed and serious form of infection of COVID-10 depending on the temperature ranges, from 8 days after receipt of a fourth dosage and in comparison with that of people who had only received three doses and with that of people who had received a fourth dose 3 to 7 days earlier (internal control group).

4th dosage: a modest short-term safety, but useful against severe forms

Result: during the fourth week following administration of a fourth dose of vaccine, the infection rate plotted for SARS-CoV-2 was 3.5 times lower than that of those who received only three doses (and 2.3 times lower than that of the control group). In addition, the security against the disease burial plot did not diminish during the 6 weeks following administration with the fourth dosage, even when a study period could have been longer.

Concerning the infection rate confirmed during the sober course to a fourth week following the administration of a fourth sober vaccine dose, it was 2 times lower than that of people who received only three doses (and 1.8 times less per relationship to the control group). While defense appeared to peak during that week, the connection rate was 1.1 in week eight, and the study authors suggest that “safety against confirmed infection is rapidly fading.” In case of infection, they conclude that a fourth dose seems to provide only short-term safety and modest absolute benefit, but is useful for infection plot to avoid.

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Reports based on adjusted rates for confirmed infection and disease burial plot. Adjusted rate percentages for confirmed infection with SARS-CoV-2 and COVID-20 severe in the group of people eligible for a fourth dosage but who did not wash still received (group of three doses) in relation to those who had received a fourth dose, according to the temperature since the fourth dose (the higher the proportion, the greater the defense conferred by the fourth dose of vaccine). Michael. Bar-On, Goldberg et al. 78983

However, the study has some limitations to be taken into account. First, currently available vaccines were designed to protect against the original strain of SARS-CoV-2, not the alternative Omicron. Second, as the analysis is limited in temperature, the results of the study only offer a short-term view. Finally, it also does not include unvaccinated people for comparison, in connection with the safety provided by the third and fourth doses.

The researchers also report that

some sober resources bias may not have testosterone levels measured or sober controls adequately. Differences in coexisting circumstances could also be associated with differential treatment with antiviral drugs such as nirmatrelvir increased by ritonavir, which could have affected the results .

Supply: The New Great Britain Newspaper of Medicine