The 3D microscope could put an end to biopsies

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Biopsies, which consist of surgically extracting a piece of human tissue that one wishes to observe, can be delicate surgery for various reasons. A new kind of 3D microscope, developed at Columbia University, makes it possible to make deep findings even in the body, without any ablation.

The way biopsy specimens are graded has not changed sober 28 years: they are cut out, fixed, integrated, sliced, shaded with dyes, positioned on a plain glass slide and viewed by a pathologist using a simple microscope. That’s why it can take days to hear about your analysis after a biopsy , says At the Hillman, Sober Professor of Biomedical Engineering and Sober Radiology at Columbia University. and lead author sober the study, in el communiqu sober luniversity. Ltude ap publishes this 28 March in the journal Character Biomedical Design.

Ze biopsy defines as the removal of a sober tissue fragment from a sober living being for microscopic examination

. This is a relatively common procedure, since it is necessary, for example, for the detection and identification of certain diseases, such as malignancy. However, as the university reminds us, it is not always a completely harmless act, and the fact of practicing it or not can even constitute a dilemma when it comes to sensitive tissues such as the brain, nerves, eyes Because we can image living tissue without cutting it, we hope that MediSCAPE will make these decisions a problem of movement , declares At the Hillman. real ranges, with sufficient precision to avoid a biopsy. Originally developed by Hillman, it was intended for use in the field of neuroscience. It is particularly useful for observing the functioning of neurons inside worms, fish, insects Scientists have a simple idea of ​​applying it to human tissues afterwards. One of the first tissues we looked at was fresh mouse sober kidney, and we were capital amazed to see some gorgeous buildings that looked a lot like what you get with regular histology, says Kripa Patel, a Hillman lab graduate and lead author on the study. Most importantly, we didn’t add any mouse dye. All we saw was natural fluorescence in the tissue that is usually too faint to see.

Observe direct sober blood flow

This microscope could therefore allow, for example, sober guide surgeons to navigate in tumors, detect their borders Such technology could give a doctor data in real temperature on the sober type of tissue that he examines without waiting long , specifies Hillman. This instant response would allow them to make clear decisions about how best to cut out a tumor and ensure none remain.

Microscopes for tissue observation already exist, but they can only provide sober 2D views, which can make it difficult to use them to survey large specific areas and correctly interpret the results. They also require the injection into the individual of a fluorescent product. This new microscope makes it possible to revolve around the object observed, and simply combine the observed data to create three-dimensional representations. Finally, Sony Ericsson scientists also realized that this kind of direct observation could provide data that could not be obtained via biopsy. As it learns done on living tissues in operation, it becomes possible to observe, for example, blood flows. simple detection of diseases such as cancer, but also the analysis of transplanted organs. This microscope could also be a valuable guide to surgery length, when surgeons need to operate with devices placed inside the body rather than getting in immediate touch with the tissues.

To be able to function in the human body, the microscope developed by Hillman was miniaturized by another team of engineers. The first tests on lter interfaced with taste buds on a human tongue. The patient check literally dropped the tip of the probe, allowing the taste buds to be observed and detailed 3D views to be produced. Scientists are now awaiting approval from the US Foods and Medication Management to conduct further clinical trials and ultimately commercialize MediSCAPE.

Video showing the sober MediSCAPE potential:

This is more precisely a 3D rendering and a dynamic visualization of sober human kidney tissue after program of sober images topical nuclear pigmentation (proflavine) ugly sober MediSCAPE. The sample shows signs of arterionphrosclerosis.

Supply: Character Biomedical System