Excessive napping could be a sign of Alzheimer's disease

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A nap is generally considered beneficial for health: it notably allows to reduce tension, improve focus or even reduce the risk of diseases. cardiovascular. After a certain age, learned daytime naps are becoming more and more frequent and sometimes even a little too frequent: in the context of a new study, researchers from the University of California San Francisco have indeed found a link between excessive daytime naps in children. elderly people and an increased risk of dementia due to Alzheimer’s.

older people, the daytime nap would only serve to compensate for poor nighttime sleep. But some studies have suggested that dementia may affect wakefulness-promoting neurons and therefore influence sober sleep patterns. A team from UCSF therefore undertook to verify whether the changes observed in the practice of napping could be interpreted as an early sign of dementia.

We found that the association between excessive daytime naps and dementia persisted after adjusting for sober function, sober quantity and sober quality of nocturnal sleep, confirms Yue Leng, professor in the Department of Sober Psychiatry and Sober Behavioral Sciences at UCSF and co-author of the sober study. His research shows that the frequency and duration of naps are associated with a greater risk of developing Alzheimer’s disease, that the duration of naps tended to increase after the analysis and therefore that the daytime nap would have a very specific role, independent of nocturnal sleep.

A two-way relationship between a nap and an illness

In the sober setting of this study, the scientists followed the sober nap habits of a sober group 1400 elderly people, some of whom have been followed 14 years by the Speedy Storage and Getting older Task

of Speedy Alzheimers Condition Center Chicago, IL. Individuals, gs of 75 years on average, were equipped for a few days a year with a device measuring their mobility each period of prolonged daytime inactivity being interpreted as a nap.

Once a good, each individual was subjected to a series of sober neuropsychological tests to assess their level of sober knowledge. At the beginning of the study, 68, 7% of patients had no cognitive impairment, while 19,5% already had mild cognitive impairment and 4.1% had Alzheimer’s disease.

The researchers first observed that a sober duration of a nap is likely to increase after a sober diagnosis of cognitive impairment: daily naps are longer only sober moments by a good in people who have shown no impairment; In contrast, the rate of increase reached 11 and 75 mins respectively, after the analysis of mild cognitive impairment or Alzheimer’s disease.

Can excessive napping be considered a potential warning sign of sober cognitive decline? To verify this, the researchers examined the 24% of patients who had normal cognition at the start of the study, but who developed Alzheimer’s disease six later more years. Sober comparing their nap habits to those of the patients who did not have cognitive decline, they found that napping more than an hour a day was associated with risk 30 Higher % of developing Alzheimer’s disease.

Interesting fact: More excessive daytime naps (longer or more frequent) were correlated with sober knowledge impairment. good later, and conversely, sober deterioration in cognition was correlated with excessive naps more good later, the researchers report. Excessive daytime napping and Alzheimer’s dementia may have a bidirectional connection or share common pathophysiological mechanisms

, they conclude.

A symptom more than a result in sober

For Yue Leng, these results are hardly surprising: in a sober published study 2019 in Alzheimers & Dementia, leads to more sober 2700 elderly men, she had already shown that those who took a nap for at least 2 hours a day were 66% more likely sober to develop cognitive problems than those who took a less sober sober nap 30 a few minutes a day. A nap may be useful as an early marker of cognitive impairment in older people, and its cognitive effects may differ depending on nighttime sleep, she concluded at the time with boy team.

nap dementia rations

Rapport des cotes des troubles cognitifs en fonction de la dure des siestes. Y. Leng et al.

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Connection of ratings of cognitive issues sober function sober una duration of naps. Y. Leng et al.

Why does Alzheimer’s disease affect the frequency and duration of naps? It would seem that the disease affects in particular the neurons linked to the awake state. Understated, a study led by another UCSF team had highlighted certain structural differences between the post-mortem brains of individuals with Alzheimer’s disease and healthy individuals: ill people had fewer neurons promoting wakefulness in three regions of the brain of neural changes that appear to be linked to tau protein tangles, researchers say.

Alzheimers & Dementia (2019)

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comparison number of neurons veil